Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Secondary mitochondrial pathology.

R C Sengers1, A M Stadhouders

  • 1Department of Paediatrics, University of Nijmegen, The Netherlands.

Journal of Inherited Metabolic Disease
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal diagnosis of NADH:ubiquinone oxidoreductase deficiency.

Prenatal diagnosis·2001
Same author

Infantile presentation of the mtDNA A3243G tRNA(Leu (UUR)) mutation.

Neuropediatrics·2001
Same author

Growth hormone treatment in children with Noonan's syndrome: four year results of a partly controlled trial.

Acta paediatrica (Oslo, Norway : 1992)·2001
Same author

Basal metabolic rate in children with a solid tumour.

European journal of clinical nutrition·2001
Same author

Novel mutations in the 7-dehydrocholesterol reductase gene of 13 patients with Smith--Lemli--Opitz syndrome.

Annals of human genetics·2001
Same author

Nuclear genes and oxidative phosphorylation disorders: a review.

European journal of pediatrics·2001
Same journal

Beyond Upper Airway Involvement: Evidence of Intrinsic Lung Disease in a Mouse Model of Mucopolysaccharidosis I.

Journal of inherited metabolic disease·2026
Same journal

Immune Dysregulation in Branched Chain Organic Acidemias.

Journal of inherited metabolic disease·2026
Same journal

Long Term Follow-Up After Transplantation in Propionic Acidemia: A Retrospective French Pediatric and Adult Cohort Study.

Journal of inherited metabolic disease·2026
Same journal

Tri-Parametric Assessment of α-Galactosidase A Activity, lysoGb3 and X-Inactivation Aids Genotype-Phenotype Categorization of Fabry Disease Female Patients.

Journal of inherited metabolic disease·2026
Same journal

Mapping the Severity of Phenylalanine Hydroxylase Deficiency.

Journal of inherited metabolic disease·2026
Same journal

Gaucher Disease Treated With Lentiviral-Mediated Gene Therapy: First Case.

Journal of inherited metabolic disease·2026
See all related articles

Many myopathies involve mitochondria, but their causes often lie outside these organelles. Understanding these external factors is crucial for diagnosing and treating mitochondrial myopathies.

Area of Science:

  • Mitochondrial biology
  • Cellular pathology
  • Neuromuscular disorders

Background:

  • Mitochondria play a vital role in cellular energy production.
  • Mitochondrial dysfunction is implicated in numerous myopathies.
  • The origins of mitochondrial myopathies are not always intrinsic to the mitochondria.

Purpose of the Study:

  • To categorize the extramitochondrial causes of myopathies.
  • To provide a framework for understanding the diverse etiologies of mitochondrial myopathies.

Main Methods:

  • Literature review and synthesis of existing research on myopathies.
  • Classification of identified causes based on their relationship to mitochondrial function.

Main Results:

Related Experiment Videos

  • Identified six categories of extramitochondrial causes for myopathies.
  • These include deficiency, intoxication, disturbed regulatory control, hypoxia, impaired organelle interaction, and unidentified factors.

Conclusions:

  • Myopathies involving mitochondria can stem from various external cellular insults.
  • Recognizing these extramitochondrial origins is essential for comprehensive diagnosis and therapeutic strategies.