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High levels of serum β2-microglobulin predict severity of coronary artery disease

Ling You1, Ruiqin Xie1, Haijuan Hu1

  • 1Division of Cardiology, The Second Hospital of Hebei Medical University, 215 Heping West Rd, Xinhua, Shijiazhuang, Hebei, 050000, People's Republic of China.

BMC Cardiovascular Disorders
|March 3, 2017
PubMed

Insights

Serum beta-2-microglobulin (B2M) is a potential biomarker for coronary artery disease (CAD). Elevated B2M levels are associated with increased CAD risk and severity, suggesting its role in cardiovascular disease progression.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Proteomics

Background:

  • Coronary artery disease (CAD) poses a significant global health threat, necessitating the identification of novel risk factors.
  • Beta-2-microglobulin (B2M) has been linked to peripheral arterial disease and adverse cardiovascular outcomes, but its role in CAD requires further investigation.
  • This study specifically examines the association between B2M and CAD in individuals without renal dysfunction.

Purpose of the Study:

  • To investigate the association between serum B2M levels and the presence and severity of coronary artery disease (CAD).
  • To determine if B2M can serve as a predictive biomarker for CAD diagnosis.
  • To evaluate the relationship between B2M levels and established CAD severity indices.

Main Methods:

  • A cohort of 1,762 subjects, including 1,359 with CAD and 403 without, were analyzed.
  • Serum B2M levels were quantified from fasting blood samples.
  • CAD severity was assessed using Gensini and SYNTAX scores, and the number of diseased vessels.

Main Results:

  • Serum B2M levels were significantly higher in CAD patients compared to controls (1.25 ± 0.46 vs 1.14 ± 0.28 mg/L, p < 0.001).
  • Elevated B2M was an independent risk factor for CAD (OR = 2.363, 95% CI: 1.467-3.906, p = 0.001).
  • B2M demonstrated moderate diagnostic capability for CAD (AUC = 0.608) and correlated positively with Gensini score, SYNTAX score, and number of diseased vessels.

Conclusions:

  • Serum B2M is significantly associated with coronary artery disease.
  • B2M may serve as a valuable biomarker for the diagnosis and risk stratification of CAD.
  • Further research is warranted to elucidate the precise mechanisms linking B2M to CAD pathogenesis.
Abstract

Keywords:
Coronary artery diseaseSeverityβ2-Microglobulin

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