Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

10.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An integrated biophysical fragment screening approach identifies novel binders of the CD28 immune receptor.

Biochemistry and biophysics reports·2026
Same author

Bile acid scaffold engineering reveals an androstane-triol derivative as a potent immunomodulator with therapeutic efficacy in EAE.

Journal of neuroinflammation·2026
Same author

Impact of preanalytical factors on blood CHI3L1 levels.

Frontiers in immunology·2026
Same author

Discovery of a CHI3L1-targeted small molecule modulating neuroinflammation in Alzheimer's disease <i>via</i> DNA-encoded library (DEL) screening.

RSC medicinal chemistry·2026
Same author

An Integrated Biophysical Fragment Screening Approach Identifies Novel Binders of the CD28 Immune Receptor.

bioRxiv : the preprint server for biology·2025
Same author

HTS-Oracle: Experimentally validated AI-enabled prioritization for generalizable small molecule hit discovery.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Mar 7, 2026

Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord
10:44

Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord

Published on: February 22, 2015

11.0K

Bone morphogenetic proteins in multiple sclerosis: Role in neuroinflammation.

Herena Eixarch1, Laura Calvo-Barreiro1, Xavier Montalban1

  • 1Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain; Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain.

Brain, Behavior, and Immunity
|March 3, 2017
PubMed
Summary

Bone morphogenetic proteins (BMPs) regulate cell fate and are implicated in multiple sclerosis (MS) pathogenesis. This review explores BMP signaling in CNS demyelination and immune modulation, offering insights into MS development and potential therapies.

Keywords:
AutoimmunityBone morphogenetic proteinsExperimental autoimmune encephalomyelitisImmune regulationMultiple sclerosisNeurodegeneration

More Related Videos

Author Spotlight: Insight Into Advances in Prion Diseases Research
10:40

Author Spotlight: Insight Into Advances in Prion Diseases Research

Published on: August 11, 2023

873
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

5.9K

Related Experiment Videos

Last Updated: Mar 7, 2026

Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord
10:44

Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord

Published on: February 22, 2015

11.0K
Author Spotlight: Insight Into Advances in Prion Diseases Research
10:40

Author Spotlight: Insight Into Advances in Prion Diseases Research

Published on: August 11, 2023

873
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

5.9K

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Bone morphogenetic proteins (BMPs) are key signaling molecules in the TGF-β superfamily.
  • Altered BMP expression is observed in multiple sclerosis (MS) patients, suggesting a role in disease pathogenesis.
  • MS is a complex autoimmune disorder affecting the central nervous system (CNS).

Purpose of the Study:

  • To review the role of BMP signaling in neuronal progenitor/stem cell fate.
  • To examine BMP expression and participation in CNS demyelination.
  • To explore BMPs' immunomodulatory functions and involvement in autoimmunity, particularly in MS.

Main Methods:

  • Literature review of existing data on BMP signaling.
  • Focus on BMPs' role in neuronal development and CNS demyelination.
  • Analysis of BMPs' impact on immune system modulation and autoimmune diseases.

Main Results:

  • BMP signaling influences neuronal progenitor/stem cell fate.
  • BMPs are involved in the regulation of CNS demyelination.
  • BMPs modulate immune responses and play a role in autoimmune and inflammatory conditions like MS.

Conclusions:

  • BMPs are multifunctional molecules with significant implications for MS pathogenesis.
  • Understanding BMP signaling in the CNS and immune system may reveal novel therapeutic targets for MS.
  • Further research into BMPs could lead to alternative treatment strategies for MS patients.