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Increased Irisin Concentrations in Patients with Crimean- Congo Hemorrhagic Fever
Seyit Ali Büyüktuna1, Halef Okan Doğan2, Deniz Bakır2
1Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, University of Cumhuriyet.
Insights
Irisin levels are elevated in Crimean-Congo Hemorrhagic Fever (CCHF) patients and correlate with certain clinical markers, suggesting a potential role in CCHF pathogenesis.
Area of Science:
- Virology
- Infectious Diseases
- Biochemistry
Background:
- Crimean-Congo Hemorrhagic Fever (CCHF) is a severe viral illness with poorly understood disease mechanisms.
- Irisin, a myokine, has emerged as a potential biomarker in various inflammatory and infectious conditions.
Purpose of the Study:
- To investigate the concentration changes of irisin in patients diagnosed with CCHF.
- To explore the correlation between irisin levels and clinical/laboratory parameters in CCHF patients.
Main Methods:
- A case-control study involving 30 CCHF patients and 30 healthy controls.
- Irisin concentrations were quantified using a commercial Enzyme-Linked Immunosorbent Assay (ELISA) kit.
- Statistical analysis was performed to assess correlations with disease severity and various laboratory markers (LDH, INR, ALT, AST, platelets, aPTT, D-dimer, hemoglobin).
Main Results:
- Median irisin concentrations were significantly higher in CCHF patients (9.03 μg/mL) compared to controls (4.2 μg/mL).
- Positive correlations were observed between irisin levels and platelet count, Alanine aminotransferase (ALT), International Normalized Ratio (INR), and activated partial thromboplastin time (aPTT).
- A negative correlation was found between irisin and lactate dehydrogenase (LDH); no significant correlations were found with AST, hemoglobin, or D-dimer.
Conclusions:
- Elevated irisin levels in CCHF patients suggest its involvement in the host response to the virus.
- Irisin may play a role in the complex pathogenesis of Crimean-Congo Hemorrhagic Fever, potentially influencing coagulation and liver function.
Abstract:
Crimean-Congo Hemorrhagic Fever (CCHF) is a life-threatening viral infection. The pathogenesis of the disease is not well understood. The aim of this study was to determine the change in irisin concentrations in patients with CCHF. The study included a total of 30 patients with CCHF and 30 control participants. Irisin concentrations were determined using a commercial ELISA kit. Median irisin concentrations were 9.03 (5.81-12.22) μg/mL and 4.2 (3.39-7.62) μg/mL, respectively, in each group. There was no correlation between irisin and disease severity. Any correlations between irisin, and lactate dehydrogenase (LDH), international normalization ratio (INR), Alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelets, activated partial thromboplastin time (aPTT), D-dimer and hemoglobin, were also investigated. There were statistically significant positive correlations between the values of irisin, and platelet (p = 0.005, r: 0.369), ALT (p = 0.049, r: 0.261), INR (p = 0.006, r: 0.359) and aPTT values (p = 0.002, r: 0.405). A negative correlation was also found between the values of irisin and LDH (p = 0.008, r: －0.348). No correlations were determined between the values of irisin, and AST, hemoglobin and D-dimer. These results suggest that irisin may have a role in CCHF.
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