Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

79
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
79

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the role of selenium in Minamata disease through reanalysis of historical samples.

Environment international·2024
Same author

Challenges in health risk assessment of multiple chemical exposures in epidemiological studies.

Environmental health and preventive medicine·2024
Same author

Correction to: Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain.

Histochemistry and cell biology·2021
Same author

Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain.

Histochemistry and cell biology·2021
Same author

Comment on "Rethinking the Minamata Tragedy: What Mercury Species Was Really Responsible?"

Environmental science & technology·2020
Same author

Cardiotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure through lactation in mice.

The Journal of toxicological sciences·2019

Related Experiment Video

Updated: Mar 7, 2026

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
09:02

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

24.6K

Developmental neurotoxicity test guidelines: problems and perspectives.

Chiharu Tohyama1

  • 1Health, Environment, Science and Technology International Consulting (HESTIC).

The Journal of Toxicological Sciences
|March 3, 2017
PubMed
Summary
This summary is machine-generated.

Early life exposure to industrial chemicals can cause developmental neurotoxicity (DNT) in children. Current testing guidelines need revision to detect low-dose effects and improve efficiency.

More Related Videos

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

594
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

13.2K

Related Experiment Videos

Last Updated: Mar 7, 2026

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
09:02

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

24.6K
Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

594
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

13.2K

Area of Science:

  • Environmental Health
  • Neuroscience
  • Toxicology

Background:

  • Epidemiologic studies link early chemical exposure to childhood cognitive and behavioral issues.
  • The developing brain is highly susceptible to chemical insult due to an immature blood-brain barrier.

Purpose of the Study:

  • To review the limitations of current developmental neurotoxicity (DNT) testing guidelines (OECD TG426).
  • To propose revisions for improved detection of DNT, especially at low exposure doses.
  • To explore cost-effective alternative testing strategies.

Main Methods:

  • Review of existing DNT test guidelines and their limitations.
  • Analysis of challenges including lack of mandated testing and data disclosure issues.
  • Consideration of in vitro/in silico alternatives and their shortcomings for higher brain functions.

Main Results:

  • Current DNT tests may fail to identify risks from low-dose chemical exposures.
  • In vivo tests are costly and time-consuming; alternative methods may not fully capture complex neurodevelopmental effects.
  • Proprietary data restrictions hinder comprehensive risk assessment.

Conclusions:

  • Existing DNT testing protocols require urgent revision to address low-dose exposures.
  • Novel in vivo testing methods should be developed and implemented, considering cost-performance.
  • Enhanced regulatory approaches are needed to ensure child neurodevelopmental safety from chemical exposure.