Related Experiment Video
Updated: Mar 7, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
Published on: July 9, 2016
Multimodal Hallucinations in Schizophrenia and Its Management
Vijaya Kumar1, Virupakshappa Bagewadi2, Dayanand Sagar2
1Department of Psychiatry, Vydehi Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India.
Multimodal hallucinations (MMHs), occurring in multiple senses simultaneously, are reported in schizophrenia. Clozapine effectively managed MMHs in two treatment-resistant schizophrenia patients, warranting further research.
Area of Science:
- Psychiatry
- Neuroscience
- Clinical Psychology
Background:
- Schizophrenia is characterized by hallucinations, which can manifest across multiple sensory modalities.
- Multimodal hallucinations (MMHs) involve simultaneous sensory experiences originating from a single source.
- Historically, MMHs were often misattributed to factitious disorder or malingering.
Observation:
- This study reports on two cases of treatment-resistant schizophrenia presenting with MMHs.
- These patients experienced complex, simultaneous hallucinations across different sensory channels.
Findings:
- Successful management of MMHs was achieved using clozapine in both reported cases.
- Clozapine demonstrated efficacy in alleviating complex hallucinatory phenomena in treatment-resistant schizophrenia.
Implications:
- The findings suggest clozapine may be a viable treatment option for schizophrenia patients with MMHs.
- Further systematic research is crucial to understand the role of MMHs in schizophrenia's course, prognosis, and treatment resistance.
- Elucidating the significance of MMHs could lead to improved diagnostic and therapeutic strategies for schizophrenia.
Related Concept Videos
Positive Symptoms Schizophrenia: Hallucinations and Delusions
Hallucinations
Hallucinations in...
Psychosis and Antipsychotic Drugs: Overview
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Psychosis: Goals of Pharmacotherapy
Drug Therapy
Antianxiety Medications
Hallucinogens and Psychedelics
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...

