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A Scanning Electron Microscopy-Compatible Optical Imaging Method for Mesoscopic All-Cell Brain Mapping

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Living Brain Optical Imaging: Technology, Methods and Applications.

Vassiliy Tsytsarev¹, Chad Bernardelli¹, Konstantin I Maslov²

¹Department of Anatomy and Neurobiology, University of Maryland School of Medicine, HSF II Room S251, 20 Penn Street, Baltimore, MD 21201-1075, USA.

Journal of Neuroscience and Neuroengineering

|March 3, 2017

Summary

This summary is machine-generated.

Optical imaging techniques offer revolutionary insights into the central nervous system. This review analyzes novel methods like optical coherence tomography and near-infrared spectroscopy for neuroscience research and clinical applications.

Keywords:

Autofluorescence Brain Imaging Diffuse Optical Tomography Imaging Metabolic – Related Optical Near-Infrared Spectroscopy Optical Coherence Tomography Optical Imaging of Intrinsic Signal Optical Imaging Photoacoustic T-Herz Voltage-Sensitive Dye

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Area of Science:

Neuroscience
Biomedical Imaging
Optical Technologies

Background:

Optical imaging has transformed the study of the central nervous system.
Advancements in optical methods provide unprecedented views into neural structures and functions.

Purpose of the Study:

To review novel optical imaging techniques for neuroscience.
To analyze the research potential and limitations of these advanced methods.
To highlight key achievements in experimental and clinical applications.

Main Methods:

Intrinsic optical imaging
Voltage-sensitive dye imaging
Photoacoustic imaging
Optical coherence tomography (OCT)
Near-infrared spectroscopy (NIRS)

Main Results:

These optical techniques offer diverse capabilities for visualizing neural activity and structure.
Significant advancements have been made in applying these methods to the central nervous system.
Some techniques show promise for both experimental research and clinical diagnostics.

Conclusions:

Novel optical imaging methods are powerful tools in modern neuroscience.
Continued development is expanding their applicability in research and clinical settings.
These techniques are crucial for advancing our understanding of the brain.