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Updated: Mar 6, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation
Chang Xia1, Xiaoquan Rao2, Jixin Zhong2
1College of Health Science & Nursing, Wuhan Polytechnic University, Wuhan, Hubei, China; Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, USA.
Abstract:
Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.
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