Bone Modifier Use as Adjuvant Therapy for Early Breast Cancer
Josee-Lyne Ethier1, Rebecca M Prince1, Eitan Amir2
1Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre and Department of Medicine, University of Toronto, 610 University Ave 5-124, Toronto, ON, M5G 2M9, Canada.
Current Oncology Reports
|March 3, 2017
Summary
Adjuvant bisphosphonates show modest benefits in reducing distant recurrence and breast cancer mortality in postmenopausal women. Routine use is not recommended for premenopausal women unless they receive ovarian function suppression.
Area of Science:
- Oncology
- Pharmacology
Background:
- Adjuvant bisphosphonates are studied for long-term breast cancer outcomes.
- Previous research yielded inconsistent results regarding their efficacy.
Purpose of the Study:
- To review the evidence for adjuvant bisphosphonates in early breast cancer.
- To analyze their role based on menopausal status.
Main Methods:
- Systematic review of existing studies and meta-analyses.
- Analysis of subgroup effects, particularly in postmenopausal women.
Main Results:
- No significant reduction in recurrence or mortality in the overall population.
- Modest reduction in distant recurrence and breast cancer mortality in postmenopausal women, primarily due to decreased bone recurrence.
- Consistent findings across studies, despite limitations in subgroup analysis.
Conclusions:
- Consider adjuvant bisphosphonates for high-risk postmenopausal women if benefits outweigh risks.
- No evidence supports routine use in premenopausal women, except in specific cases with ovarian function suppression.
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