Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone marrow granulomas in mononucleosis.

M Fiala1, I Colodro, W Talbert

  • 1Department of Medicine, Long Beach Memorial Hospital, California.

Postgraduate Medical Journal
|April 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating core surgical training selection: Associations between the Multi-Specialty Recruitment Assessment (MSRA), interview performance and offer outcomes in the 2025 UK national cohort.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2026
Same author

Diversity in Surgery: Ethnic, Gender, and LGBTQ+ Representations Among United Kingdom Surgical Residents and Consultants.

Journal of surgical education·2025
Same author

Abstracts of the 26th International Workshop on Clinical Pharmacology of HIV, Hepatitis and other Antiviral Drugs 2025, 3-4 September 2025, Amsterdam, the Netherlands.

British journal of clinical pharmacology·2025
Same author

Does training less-than-full-time predict performance at the FRCR exams?: a UKMED cohort study.

Clinical radiology·2024
Same author

Differential outcomes at the Fellowship of the Royal College of Radiologists (FRCR) exams according to demographic and socioeconomic factors.

Clinical radiology·2024
Same author

Early-life gut bacterial community structure predicts disease risk and athletic performance in horses bred for racing.

Scientific reports·2024
Same journal

Dapagliflozin-induced anaphylactic shock.

Postgraduate medical journal·2026
Same journal

Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials.

Postgraduate medical journal·2026
Same journal

Two cases of toxic epidermal necrolysis with severe ocular involvement treated with adjunctive tofacitinib.

Postgraduate medical journal·2026
Same journal

Diastolic dysfunction and diabetes: the DIADAD study-a retrospective cohort study from Liverpool.

Postgraduate medical journal·2026
Same journal

Care, cash, and proof: forensic accountability for war-related starvation.

Postgraduate medical journal·2026
Same journal

Response to traumatic injuries in polo players in England.

Postgraduate medical journal·2026
See all related articles

Bone marrow granulomas can indicate cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infections in patients with unexplained fever. This finding does not necessarily signal a worse prognosis, offering a crucial diagnostic clue.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Virology

Background:

  • Mononucleosis, a common viral illness, can present with diverse symptoms including fever and hepatitis.
  • Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are primary causes of infectious mononucleosis.
  • Differential diagnosis of unexplained fever and hepatitis can be challenging.

Observation:

  • Two cases of mononucleosis, one CMV and one EBV, presented with high fever, malaise, and hepatitis.
  • Bone marrow biopsies revealed granulomas in both patients.
  • Liver biopsies, however, did not show evidence of granulomas.

Findings:

  • The presence of bone marrow granulomas in patients with unexplained fever can be indicative of CMV or EBV infection.
  • Granulomas were localized to the bone marrow and absent in the liver in these cases.

Related Experiment Videos

  • This finding suggests a specific pattern of inflammatory response in the bone marrow during these viral infections.

    • Implications:

    • Bone marrow granulomas serve as a potential diagnostic marker for CMV and EBV mononucleosis when fever is unexplained.
    • Identifying bone marrow granulomas can guide further diagnostic workup for viral infections.
    • This observation may help clinicians avoid premature concern for more severe conditions, improving patient management and reducing unnecessary investigations.