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Consensus statement for the treatment of infantile haemangiomas with propranolol
Sarah L Smithson1, Marius Rademaker2, Susan Adams3
1Royal Children's Hospital, Melbourne, Victoria, Australia.
Insights
Infantile haemangiomas requiring intervention can be safely and effectively treated with oral propranolol. This consensus statement guides early treatment for infants with concerning haemangiomas in outpatient settings.
Area of Science:
- Paediatric Dermatology
- Vascular Anomalies
Background:
- Infantile haemangiomas often involute spontaneously but can necessitate early treatment.
- Certain haemangiomas pose risks including ulceration, functional impairment, and deformity.
Purpose of the Study:
- To provide a consensus statement for the treatment of infantile haemangiomas with oral propranolol.
- To guide early intervention strategies for high-risk infantile haemangiomas.
Main Methods:
- Development of a consensus statement by the Australasian Vascular Anomalies Network and Australasian Paediatric Dermatology Network.
- Review of evidence for oral propranolol treatment in infantile haemangiomas.
Main Results:
- Oral propranolol is recommended for infantile haemangiomas that are life-threatening, ulcerated, or cause significant impairment.
- Oral propranolol is considered safe and effective for treating infantile haemangiomas.
- Treatment with oral propranolol can be initiated in an outpatient setting for most healthy infants.
Conclusions:
- Early intervention with oral propranolol is crucial for specific infantile haemangiomas.
- Oral propranolol offers a safe and effective treatment option.
- Outpatient initiation of oral propranolol is feasible for eligible infants.
Abstract:
Although most infantile haemangiomas do not require treatment due to a natural history of spontaneous involution, some require early intervention. The Australasian Vascular Anomalies Network and the Australasian Paediatric Dermatology Network have developed a consensus statement for the treatment of infantile haemangiomas with oral propranolol. Infants with haemangiomas that are life threatening, at risk of ulceration, or at risk of causing a significant functional impairment, psychological impact or physical deformity should be treated early with oral propranolol. Oral propranolol is safe and effective and in most healthy infants oral propranolol can be started in an outpatient setting.
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