Facile synthesis and application of teicoplanin-modified magnetic microparticles for enantioseparation

A facile, mild method for the preparation of teicoplanin (TE) modified Fe₃ O₄ microparticles (MPs) employing polydopamine (PDA) layer as a versatile secondary reaction platform was developed. The synthesized magnetic MPs (Fe₃ O₄ @PDA@TE) were characterized by various characterization techniques, such as TEM, zeta potential etc, to affirm the successful modification of TE to magnetic Fe₃ O₄ MPs. Using the as-synthesized materials as chiral adsorbents, efficient chiral separation of representative racemic compounds was successfully achieved. Due to the magnetic responsivity, the materials were easily isolated from the racemic solutions under an external magnetic field and could be readily reused for at least three times. Thus, the well-prepared functional magnetic MPs have great potential in preparative chiral separation.