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Parallel changes in serum proteins and diffusion tensor imaging in methamphetamine-associated psychosis.

Michael S Breen1,2, Anne Uhlmann3, Sureyya Ozcan4

  • 1Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Scientific Reports
|March 3, 2017
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Summary

Accurate diagnosis of methamphetamine-associated psychosis (MAP) is challenging. This study reveals distinct serum protein and brain imaging patterns in MAP patients, suggesting a potential diagnostic fingerprint for this psychiatric disorder.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Biomarker Discovery

Background:

  • Methamphetamine-associated psychosis (MAP) presents complex neurocognitive and molecular deficits, complicating accurate diagnosis.
  • Current diagnostic methods for MAP lack specificity, hindering effective treatment development.

Purpose of the Study:

  • To investigate the integration of serum proteomic and diffusion tensor imaging (DTI) data for improved mechanistic understanding and diagnosis of MAP.
  • To identify potential biological markers and neuroimaging signatures associated with MAP.

Main Methods:

  • Selected reaction monitoring (SRM)-based proteomics was used to profile 43 serum proteins.
  • Diffusion tensor imaging (DTI) and psychometric assessments were conducted on patients with MAP, methamphetamine dependence (MA), and healthy controls.
  • Data integration of proteomic and DTI findings was performed to identify correlations and disruptions.

Main Results:

  • Serum protein analysis revealed significant differences in APOC2 and APOH levels in MAP patients compared to MA and control groups.
  • DTI analysis showed widespread white matter integrity loss and axon demyelination in MAP patients, indicated by increased diffusivity measures.
  • Integration of data demonstrated disrupted relationships between serum proteins and DTI measures in MA and MAP groups, particularly in brain regions vital for memory and social-emotional processing.

Conclusions:

  • Serum proteomics and DTI are sensitive tools for detecting pathophysiological changes in MAP.
  • The study suggests a potential diagnostic fingerprint for MAP based on integrated proteomic and neuroimaging data.
  • Findings provide insights into the neurobiological underpinnings of MAP, paving the way for improved diagnostics and therapeutics.