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Deformability Calculation for Estimation of the Relative Stability of Chemically Modified RNA Duplexes
Yoshiaki Masaki1, Mitsuo Sekine1, Kohji Seio1
1Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Abstract:
Chemical modification of RNA duplexes alters their stability. We have attempted to develop a computational approach to estimate the thermal stability of chemically modified duplexes. These studies revealed that the deformability of chemically modified RNA duplexes, calculated from molecular dynamics simulations, could be used as a good indicator for estimating the effect of chemical modification on duplex thermal stability. This unit describes how deformability calculation can be applied to estimate the relative stability of chemically modified RNA duplexes. © 2017 by John Wiley & Sons, Inc.
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