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Cytotoxic diterpenoids from Pteris ensiformis.

Yu-Sheng Shi1, Yan Zhang2, Wen-Zhong Hu1

  • 1a Key Laboratory of Biotechnology and Bioresources Utilization, The State Ethnic Affairs Commission-Ministry of Education , College of Life Science, Dalian Nationalities University , Dalian 116600 , China.

Journal of Asian Natural Products Research
|March 3, 2017
PubMed
Summary

Researchers discovered a new ent-kaurane diterpenoid from Pteris ensiformis, alongside known compounds. The extract and isolated compounds showed antitumor activity against cancer cell lines.

Keywords:
16α-diol-3-onePteridaceaePteris ensiformicytotoxicityent-kaurane diterpenoident-kaurane-6β

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Area of Science:

  • Natural Product Chemistry
  • Phytochemistry
  • Pharmacology

Background:

  • Pteris ensiformis is a fern species with potential medicinal properties.
  • Diterpenoids and sesquiterpenes are classes of natural products known for diverse biological activities.

Purpose of the Study:

  • To isolate and characterize chemical constituents from Pteris ensiformis.
  • To evaluate the antitumor potential of the plant extract and isolated compounds.

Main Methods:

  • Phytochemical investigation using spectroscopic methods (NMR, MS, etc.) for structure elucidation.
  • In vitro antitumor activity assay against three human cancer cell lines.

Main Results:

  • Isolation and identification of one new ent-kaurane diterpenoid (ent-kaurane-6β,16α-diol-3-one) and nine known compounds (five diterpenoids, three sesquiterpenes).
  • The ethanol extract and all isolated compounds (1-9) demonstrated antitumor activity.

Conclusions:

  • Pteris ensiformis is a source of novel ent-kaurane diterpenoids.
  • The isolated compounds possess significant antitumor properties, warranting further investigation for cancer therapy development.