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Peptide-Decorated Tunable-Fluorescence Graphene Quantum Dots.

Bedanga Sapkota1, Abdelkrim Benabbas1, Hao-Yu Greg Lin2

  • 1Department of Physics, Northeastern University , Boston, Massachusetts 02115, United States.

ACS Applied Materials & Interfaces
|March 3, 2017
PubMed
Summary

We synthesized tunable graphene quantum dots (GQDs) with strong fluorescence and high two-photon absorption. These water-stable GQDs show cell permeability and can inhibit DNA synthesis, offering potential in nanomedicine.

Keywords:
DNA bindingbiological imaginggraphene quantum dotspeptidestunable fluorescencetwo-photon fluorescence

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biochemistry

Background:

  • Graphene quantum dots (GQDs) are promising nanomaterials due to their unique optical and electronic properties.
  • Controlling GQD size, surface chemistry, and fluorescence is crucial for targeted applications.
  • Existing GQDs often face challenges with water stability and specific biological interactions.

Purpose of the Study:

  • To synthesize GQDs with controllable size, surface chemistry, and fluorescence.
  • To investigate the photophysical properties, water stability, and biological interactions of these GQDs.
  • To explore the potential of functionalized GQDs in biological systems, such as DNA synthesis inhibition.

Main Methods:

  • Synthesis of graphene quantum dots with tunable dimensions (15-35 nm).
  • Characterization of fluorescence properties, including quantum yield (0.64) and two-photon absorption (TPA) cross section (6500 GM).
  • Noncovalent surface modification to achieve water stability and introduce functional groups (e.g., lysine).

Main Results:

  • Synthesized GQDs exhibit strong visible light fluorescence and high TPA cross section.
  • Noncovalent functionalization yielded water-stable GQDs.
  • Lysine-functionalized GQDs demonstrated strong DNA binding and inhibition of polymerase-based DNA synthesis.
  • GQDs showed good cell permeability into epithelial cells but excluded from the nucleus.

Conclusions:

  • Tunable GQDs with desirable photophysical and chemical properties were successfully synthesized.
  • Functionalized GQDs offer enhanced water stability and specific biological activity.
  • These GQDs present potential for applications in bioimaging and nanomedicine, particularly in inhibiting DNA synthesis.