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Effects of Pediatric Burns on Gastrointestinal Diseases: A Population-Based Study
James H Boyd1, Fiona M Wood, Sean M Randall
1From the *Centre for Data Linkage, Curtin University, Western Australia, Perth, Australia; †Burn Injury Research Unit, School of Surgery, University of Western Australia, Western Australia, Perth, Australia; and ‡Burns Service of Western Australia, Fiona Stanley Hospital and Princess Margaret Hospital, Western Australia, Perth, Australia.
Insights
Pediatric burn survivors face double the rate of gastrointestinal disease hospitalizations and longer stays post-discharge. This highlights a significant long-term health risk following burn injuries in children.
Area of Science:
- Pediatric Gastroenterology
- Burn Injury Outcomes
- Public Health Research
Background:
- Systemic responses to burns can affect the gastrointestinal tract.
- Long-term gastrointestinal morbidity following pediatric burns is not well understood.
Purpose of the Study:
- To determine if pediatric burns are associated with increased hospital use for gastrointestinal diseases after initial discharge.
- To assess the long-term gastrointestinal health outcomes in children following burn injuries.
Main Methods:
- Population-based longitudinal study using linked hospital and death data from Western Australia (1980-2012).
- Inclusion of 10,436 children hospitalized for a first burn injury and 40,819 matched controls.
- Analysis of admission rates, length of stay, and incident gastrointestinal diseases using negative binomial and Cox regression models.
Main Results:
- The pediatric burn cohort showed twice the rate of gastrointestinal disease admissions (IRR: 2.03) and hospital stays (IRR: 2.23) compared to controls.
- Burn survivors had a higher rate of first-time gastrointestinal disease admissions (HR: 1.18).
- Adjustments were made for demographic and pre-existing health factors.
Conclusions:
- Pediatric burn hospitalizations are linked to increased postburn hospital service use for gastrointestinal diseases.
- Children with burn injuries face a heightened risk of long-term gastrointestinal morbidity.
- Findings underscore the need for monitoring and management of gastrointestinal health in pediatric burn survivors.
Abstract:
The systemic responses triggered by burns have been shown to include effects on the gastrointestinal tract. However, it is not clear if these changes lead to long-term gastrointestinal morbidity in patients with burns. The aim of this study was to assess if pediatric burns are associated with increased hospital use for gastrointestinal diseases after discharge for the initial injury. A population-based longitudinal study was performed using linked hospital and death data from Western Australia for children younger than 15 years when hospitalized for a first burn injury (n = 10,436) between 1980 and 2012, along with a frequency-matched noninjury comparison cohort, randomly selected from Western Australia's birth registrations (n = 40,819). Crude admission rates and cumulative length of stay for digestive diseases were calculated. Negative binomial and Cox proportional hazards regression modeling were used to generate incidence rate ratios (IRRs) and hazard ratios, respectively. After discharge, the pediatric burn cohort experienced twice the rate of gastrointestinal disease admissions (IRR, 95% confidence interval [CI]: 2.03, 1.56-2.65), spent over twice as long in hospital (IRR, 95% CI: 2.23, 1.67-2.98), and had a higher rate of first-time or incident gastrointestinal disease admissions (hazard ratio, 95% CI: 1.18, 1.08-1.29) when compared with the uninjured cohort, after adjusting for demographic and preexisting health factors. Children who experience a burn injury hospitalization are at increased risk of postburn hospital service use for gastrointestinal diseases when compared with uninjured children.
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