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White-coat hypertension is a risk factor for cardiovascular diseases and total mortality

Yuli Huang1, Weijun Huang, Weiyi Mai

  • 1aDepartment of Cardiology, Nanfang Hospital, Southern Medical University, GuangzhoubDepartment of Cardiology, The Affiliated Hospital at Shunde (the First People's Hospital of Shunde), Southern Medical UniversitycDepartment of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, GuangzhoudDepartment of Cardiology, the Central Hospital of Xiangtan, Xiangtan, PR China.

Journal of Hypertension
|March 3, 2017
PubMed

Insights

White-coat hypertension (WCH) increases cardiovascular disease (CVD) and mortality risk in untreated patients. However, WCH poses no increased risk for treated patients, indicating the importance of monitoring.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Public Health

Background:

  • White-coat hypertension (WCH) is a controversial phenomenon.
  • Its association with adverse cardiovascular outcomes requires further investigation.

Purpose of the Study:

  • To evaluate the association between WCH and the risk of cardiovascular diseases (CVDs) and mortality.
  • To stratify these risks based on baseline antihypertensive treatment status.

Main Methods:

  • A systematic review and meta-analysis of prospective studies.
  • Inclusion of data from 23 cohorts comprising over 20,000 individuals.
  • Calculation of relative risks for CVD and total mortality compared to normotension.

Main Results:

  • In untreated patients, WCH was linked to a 38% increased CVD risk and 20% increased mortality risk.
  • In treated patients, WCH showed no significant increase in CVD or mortality risk.
  • Meta-regression found no correlation between blood pressure variations and CVD risk in WCH.

Conclusions:

  • WCH is associated with long-term CVD and mortality risks, particularly in untreated individuals.
  • Close follow-up is recommended for patients with WCH.
Abstract

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