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Polyclonal antibody secretion during acute graft-versus-host disease
O Ringdén1, B Sundberg, L Markling
1Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
Scandinavian Journal of Immunology
|November 1, 1987
Summary
Bone marrow transplantation (BMT) recipients showed reduced spontaneous plaque-forming cells (S-PFC). Acute graft-versus-host disease (GVHD) significantly increased S-PFC, correlating with severity.
Area of Science:
- Immunology
- Hematology
Background:
- Spontaneous plaque-forming cells (S-PFC) are crucial indicators of B-cell activity.
- Bone marrow transplantation (BMT) can significantly impact immune reconstitution.
- Graft-versus-host disease (GVHD) is a major complication following allogeneic BMT.
Purpose of the Study:
- To investigate the dynamics of S-PFC in patients undergoing BMT.
- To assess the relationship between S-PFC levels and the development of acute GVHD.
- To evaluate the long-term effects of BMT on S-PFC.
Main Methods:
- Longitudinal monitoring of S-PFC in 67 BMT recipients and 41 controls.
- Categorization of patients based on the presence and severity of acute GVHD.
- Comparison of S-PFC levels between patient groups and controls at various time points post-BMT.
Main Results:
- S-PFC were generally reduced post-BMT compared to controls.
- Acute GVHD was associated with a marked increase in IgG, IgA, and IgM S-PFC, particularly in the initial 4 weeks.
- S-PFC levels correlated positively with the severity of acute GVHD.
- Post-acute GVHD resolution, IgA and IgM S-PFC decreased significantly.
- Long-term BMT survivors (>1 year) showed reduced IgM S-PFC.
Conclusions:
- S-PFC levels are significantly altered following BMT.
- Acute GVHD is characterized by a substantial enhancement of S-PFC.
- S-PFC serve as a potential biomarker for monitoring immune status post-BMT and during GVHD.