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MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease

P H Reddy1, J Williams2, F Smith2

  • 1Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, United States; Texas Tech University Health Sciences Center, Lubbock, TX, United States.

Progress in Molecular Biology and Translational Science
|March 4, 2017
PubMed

Insights

MicroRNAs (miRNAs) are key indicators in aging and cellular senescence. This review explores their role in age-related diseases like Alzheimer's and evaluates miRNA-based therapies.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Neuroscience

Background:

  • Aging involves cellular changes like oxidative damage, telomere shortening, and inflammation, leading to senescence.
  • These changes contribute to age-related diseases, including neurodegenerative conditions and cancer.
  • The precise molecular mechanisms underlying aging and associated diseases require further elucidation.

Purpose of the Study:

  • To review recent advances in understanding microRNAs (miRNAs) in aging and cellular senescence.
  • To explore the specific involvement of miRNAs in age-related diseases, with a focus on Alzheimer's disease (AD).
  • To critically assess miRNA-based therapeutic targets for aging and AD.

Main Methods:

  • Literature review of recent advancements in miRNA research related to aging.
  • Analysis of studies investigating miRNA involvement in cellular senescence and age-related diseases.
  • Evaluation of current and potential miRNA-based therapeutic strategies.

Main Results:

  • MicroRNAs (miRNAs) are emerging as significant biomarkers for aging, cellular senescence, and Alzheimer's disease.
  • Specific miRNAs are implicated in the cellular processes that drive aging and the pathogenesis of age-related diseases.
  • miRNA dysregulation is a common feature across various age-related conditions.

Conclusions:

  • MicroRNAs play a crucial role in the molecular pathways of aging and cellular senescence.
  • miRNAs hold significant potential as diagnostic and prognostic biomarkers for age-related diseases, particularly AD.
  • Targeting miRNAs offers a promising therapeutic avenue for combating aging and associated pathologies.
Keywords:
Alzheimer's diseaseMicroRNAsMitochondrial dysfunctionPhosphorylated tauSynaptic damage

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