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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
Published on: April 26, 2017
Osteopontin splice variants and polymorphisms in cancer progression and prognosis
Marco Antonio Briones-Orta1, S Eréndira Avendaño-Vázquez2, Diana Ivette Aparicio-Bautista2
1Regeneration and Repair, Institute of Hepatology, Foundation for Liver Research, London, United Kingdom.
Abstract:
Osteopontin (OPN) is an extracellular matrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we review the roles of OPN splice variants (a, b, c) in cancer development, progression, and prognosis, and also discuss the identities of isoforms 4 and 5. We also discussed how single-nucleotide polymorphisms (SNPs) of the OPN gene are an additional factor influencing the level of OPN in individuals, modulating the risks of cancer development and outcome.
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