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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Cdk6 contributes to cytoskeletal stability in erythroid cells.

Iris Z Uras1, Ruth M Scheicher1, Karoline Kollmann1

  • 1Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.

Haematologica
|March 4, 2017
PubMed
Summary

Cyclin-dependent kinase 6 (Cdk6) deficiency in mice causes anemia by affecting erythrocyte lifespan and mechanical stress sensitivity. Cdk6 impacts the actin cytoskeleton, suggesting therapeutic relevance for anemia and cancer treatments.

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