Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoregulation of Blood Flow

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vasopressin Improves Cerebral Perfusion Pressure but Not Cerebral Blood Flow or Tissue Oxygenation in Patients with Subarachnoid Hemorrhage and Norepinephrine-Refractory Hypotension: A Preliminary Evaluation.

Journal of clinical medicine·2025

Same author

The Three-Dimensional Growth of Traumatic Intracerebral Hemorrhage in Patients with Abnormal Coagulation.

Journal of neurological surgery. Part A, Central European neurosurgery·2025

Same author

Fast simulation of hemodynamics in intracranial aneurysms for clinical use.

Acta neurochirurgica·2025

Same author

NS-HGlio: A generalizable and repeatable HGG segmentation and volumetric measurement AI algorithm for the longitudinal MRI assessment to inform RANO in trials and clinics.

Neuro-oncology advances·2023

Same author

Breakouts-A Radiological Sign of Poor Prognosis in Patients With Brain Metastases.

Frontiers in oncology·2022

Same author

Surgical resection of symptomatic brain metastases improves the clinical status and facilitates further treatment.

Cancer medicine·2020

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Detection of Impaired Cerebral Autoregulation Using Selected Correlation Analysis: A Validation Study.

Martin A Proescholdt¹, Rupert Faltermeier¹, Sylvia Bele¹

¹Department of Neurosurgery, University Hospital Regensburg, Regensburg, Germany.

Computational and Mathematical Methods in Medicine

|March 4, 2017

Summary

Selected Correlation Analysis (SCA) effectively detects impaired cerebral autoregulation in multimodal brain monitoring data. This method shows high sensitivity and specificity, aiding in timely diagnosis and improved patient outcomes for neurological conditions.

More Related Videos

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

Related Experiment Videos

Last Updated: Jul 6, 2026

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

Area of Science:

Neuroscience
Medical Technology
Data Analysis

Background:

Multimodal brain monitoring is crucial for treating critical neurological diseases.
Managing large datasets from monitoring requires integrated tools for timely pathological event detection.
Previous work introduced a mathematical model for simulating reduced intracranial compliance and impaired autoregulation.

Purpose of the Study:

To compare the efficacy of Selected Correlation Analysis (SCA) with the Pressure Reactivity Index (PRx) for detecting impaired autoregulation.
To evaluate SCA's sensitivity and specificity in identifying cerebral autoregulation failure.
To assess the correlation between autoregulation failure and patient outcomes.

Main Methods:

Utilized Selected Correlation Analysis (SCA), a mathematical toolset, to detect correlation patterns indicative of impaired autoregulation in patient data.
Compared SCA results with the Pressure Reactivity Index (PRx), a known marker for impaired autoregulation.
Analyzed sensitivity and specificity of SCA in predicting autoregulation failure.

Main Results:

Mean PRx values were significantly higher in segments identified by SCA as having impaired autoregulation (scp) compared to those without (nsc).
SCA demonstrated a sensitivity of 78.8% and a specificity of 62.6% in predicting cerebral autoregulation failure.
Autoregulation failure, identified by both methods, significantly correlated with poor patient outcomes.

Conclusions:

SCA is a sensitive and specific tool for detecting impaired autoregulation in multimodal brain monitoring data.
SCA facilitates simultaneous detection of disturbed autoregulation and reduced intracranial compliance.
SCA holds potential as a valuable analysis tool for multimodal brain monitoring.