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Well-differentiated adenocarcinoma associated with ulcerative colitis
Tomoko Yamamoto1, Atsuko Hiroi1, Hiroko Itagaki1
1Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan; Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan.
SAGE Open Medical Case Reports
|March 4, 2017
Summary
Diagnosing well-differentiated adenocarcinoma in ulcerative colitis is challenging. This case highlights difficulties and potential biomarkers like CK7, TNF-α, Aurora B, CD44v6, and ADAM 17 for improved detection.
Area of Science:
- Gastroenterology and Oncology
- Molecular Pathology
Background:
- Adenocarcinoma diagnosis in ulcerative colitis (UC) patients presents significant clinical and pathological challenges.
- Early detection is crucial for effective management and improved patient outcomes.
Observation:
- A case of extremely well-differentiated adenocarcinoma associated with UC is presented.
- Preoperative diagnosis was hindered by biopsy findings mimicking low-grade dysplasia or regenerative mucosa.
- Postoperative diagnosis confirmed carcinoma, necessitating surgical intervention due to severe stenosis.
Findings:
- Immunohistochemical analysis revealed distinct differences between tumor cells and mucosal lesions.
- Increased expression of CK7, TNF-α, and Aurora B was noted in invasive adenocarcinoma cells.
- Altered expression of adhesion molecule CD44v6 and sheddase ADAM 17 was observed in invasive glands.
Implications:
- These findings offer insights into the pathogenesis of adenocarcinoma in UC.
- The identified biomarkers may aid in the diagnosis of challenging, well-differentiated adenocarcinoma cases.
- Further research is warranted to validate these markers for clinical application in UC-associated neoplasia.
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