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Antibody Mimetics, Peptides, and Peptidomimetics
Xiaoying Zhang1, Thirumalai Diraviyam2,3
1College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, 712100, Shaanxi, China. zhang.xy@nwsuaf.edu.cn.
Methods in Molecular Biology (Clifton, N.J.)
|March 4, 2017
Summary
Scientists are developing antibody mimetics as advanced biomedical agents, overcoming limitations of traditional antibodies. These engineered proteins offer new therapeutic and diagnostic possibilities, with some already reaching the market.
Area of Science:
- Biotechnology
- Protein Engineering
- Drug Discovery
Background:
- Traditional antibodies (polyclonal and monoclonal) face limitations in therapeutic and diagnostic applications.
- Next-generation biomedical agents, termed antibody mimetics, are being developed to overcome these limitations.
- Antibody mimetics offer advantages over conventional antibodies for various biomedical uses.
Purpose of the Study:
- To provide an overview of the characteristics, construction, and applications of antibody mimetics.
- To highlight the progress in designing and selecting antibody mimetics.
- To discuss the potential of antibody mimetics in areas where conventional antibodies are ineffective.
Main Methods:
- Antibody mimetics are designed using protein-directed evolution or by fusing complementarity-determining regions with framework regions.
- Display technologies, utilizing human, butterfly (Pieris brassicae), and bacterial systems, are employed for mimetic design and selection.
- Extensive progress has been made in the last decade utilizing these systems.
Main Results:
- Several antibody mimetics have been successfully designed and selected using various systems and display technologies.
- Some developed antibody mimetics have already entered the market, demonstrating commercial viability.
- Significant advancements have been achieved in the design and application of these novel agents.
Conclusions:
- Antibody mimetics represent a promising class of next-generation biomedical agents.
- Further development is needed to address limitations and expand the use of mimetics, especially for challenging biomedical applications.
- Antibody mimetics hold potential for future therapeutic, diagnostic, and detection applications.
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