Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Potentiometry: Membrane Electrodes

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tunable electrostatic interactions of lipid-coated quantum dots with biological membranes.

bioRxiv : the preprint server for biology·2026

Same author

Scattering-based super-resolution optical fluctuation imaging.

Optics express·2025

Same author

Toward measurements of absolute membrane potential in Bacillus subtilis using fluorescence lifetime.

Biophysical reports·2025

Same author

Towards measurements of absolute membrane potential in Bacillus subtilis using fluorescence lifetime.

bioRxiv : the preprint server for biology·2024

Same author

Long-Chain Lipids Facilitate Insertion of Large Nanoparticles into Membranes of Small Unilamellar Vesicles.

Langmuir : the ACS journal of surfaces and colloids·2024

Same author

The actin cytoskeleton: Morphological changes in pre- and fully developed lung cancer.

Biophysics reviews·2024

Same journal

Enhanced-Sampling Simulations Reveal Distinct Intermediates in SARS-CoV-2 FSE Pseudoknot Interconversion.

Biophysical journal·2026

Same journal

Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of an infection-critical peptide externalization event.

Biophysical journal·2026

Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026

Same journal

Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

Biophysical journal·2026

Same journal

Kinesin-5/Cut7 C-terminal tail phosphorylation influence on motor regulation through multi-scale molecular modeling.

Biophysical journal·2026

Same journal

Dynamic conformations of fluorophores on self-labeling protein tags.

Biophysical journal·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 6, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Design Rules for Membrane-Embedded Voltage-Sensing Nanoparticles.

Kyoungwon Park¹, Shimon Weiss²

¹Department of Electrical Engineering, University of California Los Angeles, Los Angeles, California.

Biophysical Journal

|March 4, 2017

Summary

This summary is machine-generated.

Semiconducting nanoparticles show promise as novel voltage sensors for neuroscience. Quantum mechanical calculations explore their potential for detecting neural activity in live brains.

More Related Videos

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

Related Experiment Videos

Last Updated: Mar 6, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

Published on: December 2, 2022

Area of Science:

Neuroscience
Materials Science
Quantum Chemistry

Background:

Voltage-sensing dyes and fluorescent proteins have advanced neuronal circuit studies.
Current voltage sensors face limitations in detecting single action potentials across large fields of view in live mammalian brains.

Purpose of the Study:

To investigate semiconducting nanoparticles as potential membrane voltage sensors.
To provide design rules for optimizing nanoparticle sensors for neural activity detection.

Main Methods:

Quantum mechanical calculations were performed.
Auger recombination rates and the quantum-confined Stark effect in membrane-embedded nanoparticles were analyzed.

Main Results:

The study examined the utility of semiconducting nanoparticles as membrane voltage sensors.
Design principles for nanoparticle structure and composition were established.

Conclusions:

Semiconducting nanoparticles offer a promising alternative for advanced voltage sensing in neuroscience.
Further development based on the provided design rules could enable routine detection of neural activity.