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Updated: Mar 6, 2026
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Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy
Published on: June 25, 2013
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[Deep versus moderate neuromuscular block during one-lung ventilation in lung resection surgery]
Javier Casanova1, Patricia Piñeiro1, Francisco De La Gala1
1Hospital Gregorio Marañon, Madrid, Espanha.
Revista Brasileira De Anestesiologia
|March 4, 2017
Summary
Deep neuromuscular blockade improves respiratory function during one-lung ventilation in thoracic surgery. This study found that intense and deep blockade enhanced lung mechanics and oxygen saturation, contrary to previous concerns.
Area of Science:
- Anesthesiology
- Thoracic Surgery
- Respiratory Physiology
Background:
- Neuromuscular relaxants are vital in general anesthesia.
- Concerns exist regarding neuromuscular blockade's impact during one-lung ventilation in thoracic surgery.
Purpose of the Study:
- To compare respiratory function based on the degree of neuromuscular relaxation.
- To evaluate if neuromuscular blockade during one-lung ventilation is detrimental.
Main Methods:
- Prospective, longitudinal observational study of 76 patients undergoing lung resection.
- Patients served as their own controls, with data collected during varying levels of neuromuscular blockade (intense, deep, moderate).
- Ventilator and hemodynamic data were recorded during one-lung ventilation in lateral decubitus.
Main Results:
- Peak, plateau, and mean airway pressures were significantly lower with intense and deep blockade.
- Lung compliance and peripheral oxygen saturation were significantly higher during intense and deep blockade.
- Heart rate increased significantly during deep blockade; no mechanical ventilation parameters were altered.
Conclusions:
- Deep neuromuscular blockade mitigates the adverse lung mechanics associated with one-lung ventilation.
- Findings suggest that deep neuromuscular blockade is beneficial, not deleterious, during one-lung ventilation in thoracic surgery.
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