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Liver Histology

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...

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Related Experiment Video

Updated: Mar 6, 2026

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

Published on: February 2, 2024

Variant differentiation patterns in primary liver carcinoma.

Christine Sempoux¹, Valérie Paradis², Romil Saxena³

¹Service of Clinical Pathology, Lausanne University Hospital, Institute of Pathology, 25 rue du Bugnon, CH-1011 Lausanne, Switzerland.

Seminars in Diagnostic Pathology

|March 4, 2017

Summary

This summary is machine-generated.

Primary liver cancers are becoming more complex, with new forms showing mixed cell features. Further research is needed to define their diagnosis, prognosis, and treatment for better patient outcomes.

Area of Science:

Hepatobiliary pathology
Tumor differentiation
Oncology

Background:

Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are distinct primary liver cancers.

Keywords:

Bi-phenotypic differentiation Cholangiocarcinoma Cholangiolocellular carcinoma Combined hepatocellular-cholangiocarcinoma Combined primary liver carcinoma Hepatocellular carcinoma Mixed primary liver carcinoma Progenitor cells Stem cells Trans-differentiation

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Emerging variants exhibit biphenotypic, stem/progenitor cell, or other unusual differentiation patterns.

These challenging tumors complicate traditional diagnostic paradigms.