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Checkpoint-based immunotherapy for autoimmune diseases - Opportunities and challenges

Xiao-Song He1, M Eric Gershwin1, Aftab A Ansari2

  • 1Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, United States.

Journal of Autoimmunity
|March 4, 2017
PubMed
Summary

Immune checkpoint pathways regulate T cell responses, but their dysregulation causes autoimmune diseases. Checkpoint-based immunotherapy offers a promising strategy for restoring T cell tolerance, but requires organ-specific targeting.

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