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Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

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Related Experiment Video

Updated: Mar 6, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

Levodopa response differs in Parkinson's motor subtypes: A task-based effective connectivity study.

Brianne Mohl¹, Brian D Berman^1,2,3,4, Erika Shelton²

¹Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

The Journal of Comparative Neurology

|March 4, 2017

Summary

This summary is machine-generated.

Levodopa affects brain activity differently in Parkinson's disease (PD) motor subtypes. Tremor-dominant PD patients showed altered connectivity, while postural instability/gait difficulty PD patients had increased putamen activation after medication.

Keywords:

Parkinson's disease RRID:SCR_007037 RRID:SCR_009489 functional MRI postural instability/gait difficulty psychophysiological interaction tremor dominant

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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Area of Science:

Neuroimaging
Movement Disorders
Neurology

Background:

Parkinson's disease (PD) is characterized by distinct motor subtypes.
Subtype-specific pathophysiology and levodopa response remain unclear.
Few studies investigate levodopa's effect on neural activation across PD motor subtypes.

Purpose of the Study:

To examine task-induced neural activation and connectivity in the motor circuit.
To compare healthy controls, tremor-dominant (TD), and postural instability/gait difficulty (PIGD) PD subtypes.
To assess the impact of levodopa on these neural responses.

Main Methods:

Functional MRI (fMRI) during a paced tapping task.
Inclusion of 14 TD, 12 PIGD patients, and 21 healthy controls.
Assessment of brain activity and effective connectivity off and on levodopa.

Main Results:

PD patients off medication showed reduced motor cortex activation.
PIGD patients exhibited increased left putamen activation post-levodopa compared to TD and controls.
Levodopa enhanced posterior putamen connectivity in TD patients, but not PIGD patients.

Conclusions:

Levodopa induces distinct neural response patterns in PD motor subtypes.
These findings may help elucidate subtype-specific mechanisms.
Objective fMRI-based classification of PD motor subtypes is a potential future application.