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Amino-functionalized mesoporous bioactive glass for drug delivery
Shengxiang Jiang1, Yin Zhang1,2, Yan Shu1
1College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 210009, People's Republic of China.
Biomedical Materials (Bristol, England)
|March 4, 2017
Summary
Amino-functionalized mesoporous bioactive glass (N-MBG) offers enhanced drug loading and extended release. This bioactive glass demonstrates improved properties for drug delivery applications.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Drug Delivery Systems
Background:
- Mesoporous bioactive glasses (MBG) are advanced materials for biomedical applications.
- Optimizing MBG for enhanced drug loading and controlled release remains a key research area.
Purpose of the Study:
- To develop an amino-functionalized MBG (N-MBG) with superior drug carrying capacity and prolonged drug release.
- To investigate the effect of amination on the physicochemical properties and drug release kinetics of MBG.
Main Methods:
- Synthesis of N-MBG via a short-time chemical reaction using 3-aminopropyltriethoxysilane (APTES).
- Characterization of surface area, pore structure, and surface charge (zeta-potential) of MBG and N-MBG.
- Drug loading and in vitro release studies using gentamicin sulfate (GS) in simulated body fluid.
Main Results:
- N-MBG exhibited a higher surface area (355.01 m²/g) compared to MBG (288.07 m²/g).
- Surface zeta-potential shifted from negative (-10.06 mV) for MBG to positive (+5.30 mV) for N-MBG.
- GS loading rate was significantly higher for N-MBG (62.92%) than MBG (48.90%).
- N-MBG demonstrated a longer drug release profile, with lower cumulative release (45.9%) over seven days compared to MBG (60.7%).
- In vitro bioactivity tests confirmed good biological activity of N-MBG.
Conclusions:
- Amination effectively enhances the drug loading capacity and extends the drug release duration of mesoporous bioactive glass.
- N-MBG presents a promising platform for advanced drug delivery systems due to its improved physicochemical properties and drug release kinetics.
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