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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Cytotoxic Naphthoquinone and Azaanthraquinone Derivatives from an Endophytic Fusarium solani
Nargis Sultana Chowdhury1,2,3, Md Hossain Sohrab1, Md Sohel Rana3
1Pharmaceutical Sciences Research Division (PSRD), BCSIR Laboratories, Dhaka , Dr. Qudrat-I-Khuda Road, Dhanmondi, Dhaka, Bangladesh.
Abstract:
Bioactivity-guided fractionation of the ethyl acetate extract obtained from the culture of the endophytic fungus Fusarium solani resulted in the isolation of one new naphthoquinone, 9-desmethylherbarine (1), and two azaanthraquinone derivatives, 7-desmethylscorpinone (2) and 7-desmethyl-6-methylbostrycoidin (3), along with four known compounds. Their structures were elucidated by spectral analysis, as well as a direct comparison of spectral data with those of known compounds. Azaanthraquinones 2 and 3 showed cytotoxic activity against four human tumor cell lines, MDA MB 231, MIA PaCa2, HeLa, and NCI H1975. A molecular docking study suggested DNA interactions as the mode of action of these naphthoquinones and azaanthraquinones.
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