Clinical Effect and Prognosis of Off-Pump Minimally Invasive Direct Coronary Artery Bypass
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Updated: Mar 6, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Ming Yang1, Lian-Bo Xiao1, Zhi-Sheng Gao2
1Department of Cardiothoracic Surgery, Cangzhou City Central Hospital, Cangzhou, Hebei, China (mainland).
Insights
Minimally invasive direct coronary artery bypass (MIDCAB) offers similar clinical benefits to off-pump coronary artery bypass grafting (OP-CABG). MIDCAB significantly reduces hospital stay and blood transfusions, improving patient prognosis.
Area of Science:
- Cardiovascular Surgery
- Minimally Invasive Procedures
- Cardiac Bypass Techniques
Background:
- Coronary artery bypass grafting (CABG) is a common surgical intervention for coronary artery obstruction when stents are unsuitable.
- Traditional CABG is highly invasive, involving cardiopulmonary bypass, and carries significant perioperative risks.
- Minimizing risks associated with CABG surgery is crucial for improving patient outcomes.
Purpose of the Study:
- To compare the clinical efficacy and safety of minimally invasive direct coronary artery bypass (MIDCAB) versus off-pump coronary artery bypass grafting (OP-CABG).
- To evaluate the impact of MIDCAB on surgical bleeding, postoperative recovery, and long-term clinical prognosis.
Main Methods:
- A cohort of 126 patients with coronary artery syndrome unsuitable for percutaneous coronary intervention was divided into two groups.
- The observation group underwent minimally invasive direct coronary artery bypass (MIDCAB).
- The control group was treated with off-pump coronary artery bypass (OP-CABG).
Main Results:
- Both MIDCAB and OP-CABG groups showed comparable improvements in blood markers and echocardiography.
- No significant adverse reactions or organ damage (liver, kidney) were observed in either group.
- The MIDCAB group demonstrated significantly reduced surgical bleeding, shorter postoperative hospital stays, and lower rates of death and cardiac shock post-follow-up.
Conclusions:
- Minimally invasive direct coronary artery bypass (MIDCAB) and off-pump coronary artery bypass grafting (OP-CABG) provide similar overall clinical benefits.
- MIDCAB significantly reduces postoperative hospital stay and the need for intraoperative blood transfusions.
- MIDCAB is associated with an improved clinical prognosis compared to OP-CABG.
Abstract:
BACKGROUND Coronary artery bypass grafting (CABG) is a common procedure to circumvent the obstruction of coronary arteries when stents are unsuitable. CABG is a very traumatic surgery that requires redirecting blood flow to an external pump. Thus, this procedure has many risks during and after surgery, and minimizing these risks would greatly benefit the patients. MATERIAL AND METHODS We selected 126 patients with coronary artery syndrome and who were unsuitable for stent percutaneous coronary intervention. The observation group received minimally invasive direct coronary artery bypass (MIDCAB), while the control group was treated with off-pump CABG. RESULTS Blood markers and echocardiography before and after treatment improved equally in both groups. Neither group exhibited obvious adverse reactions, or liver and kidney function damage. However, surgical bleeding and postoperative observation days were significantly reduced in the MIDCAB group. Death and cardiac shock at the end of follow-up were significantly lower in the MIDCAB group. CONCLUSIONS Overall, the clinical benefits of MIDCAB and OP-CABG were similar, but MIDCAB significantly reduced postoperative hospital stay and intraoperative blood transfusion, and improved clinical prognosis.

