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Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing

Yeunkum Lee1, Ji Soo Lee2, Kea Joo Lee3

  • 1Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007-2126, USA; Department of Neuroscience and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul, 02841, South Korea.

Neuropharmacology
|March 5, 2017
PubMed

Keywords:
Alzheimer's diseaseAmyloidogenic processingHyperexcitationNeurodegenerationNeuronal signalingPolo-like kinase 2Synaptic plasticity

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