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Updated: Mar 6, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

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Thrombophilia risk is not increased in children after perinatal stroke

Colleen Curtis1,2, Aleksandra Mineyko1,2,3,4, Patricia Massicotte5

  • 1Department of Pediatrics.

Blood
|March 5, 2017
PubMed

Insights

This study found minimal association between perinatal stroke and thrombophilia in children. Routine thrombophilia testing in childhood is not indicated for perinatal stroke cases.

Area of Science:

  • Neurology
  • Pediatrics
  • Hematology

Background:

  • Perinatal stroke leads to cerebral palsy and lifelong disability.
  • Mechanisms of perinatal stroke remain poorly understood.
  • Limited population-based studies exist on thrombophilia in perinatal stroke.

Purpose of the Study:

  • To determine the association between specific perinatal stroke diseases and known thrombophilias.
  • To inform pathogenesis models and clinical management of perinatal stroke.
  • To investigate neonatal arterial ischemic stroke (NAIS), arterial presumed perinatal ischemic stroke (APPIS), and fetal periventricular venous infarction (PVI).

Main Methods:

  • Prospective, population-based, case-control study of 212 children.
  • Included children with NAIS, APPIS, PVI, and controls.
  • Standardized thrombophilia evaluations performed after 12 months of age.

Main Results:

  • No significant differences in 12 of 14 thrombophilia parameters between cases and controls.
  • Rates of antiphospholipid antibodies were low and comparable to controls.
  • Factor V Leiden (FVL) and Factor II G20210A (FII) rates were comparable to population norms.

Conclusions:

  • Minimal association observed between perinatal stroke and thrombophilia.
  • Does not exclude disordered coagulation at the time of stroke.
  • Childhood thrombophilia testing is not indicated for perinatal stroke.

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