The role of APOE on lipid homeostasis and inflammation in normal brains
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Updated: Mar 6, 2026

Quantification of Atherosclerosis in Mice
Published on: June 12, 2019
1Department of Neuroscience, Georgetown University Medical Center, Washington, DC.
Abstract:
The role of APOE in the risk of Alzheimer's disease (AD) has largely focused on its effects on AD pathological processes. However, there are increasing data that APOE genotype affects processes in normal brains. Studies of young cognitively normal humans show effects of APOE genotype on brain structure and activity. Studies of normal APOE knock-in mice show effects of APOE genotype on brain structure, neuronal markers, and behavior. APOE interactions with molecules important for lipid efflux and lipid endocytosis underlie effects of APOE genotype on neuroinflammation and lipoprotein composition. These effects provide important targets for new therapies for reduction of the risk of AD before any signs of pathogenesis.
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