Single-cell transcriptomics reveals specific RNA editing signatures in the human brain
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Updated: Mar 6, 2026

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Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing
Published on: December 3, 2019
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Ernesto Picardi1,2, David S Horner3, Graziano Pesole1,2
1Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, 70126 Bari, Italy.
Abstract:
While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.

