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RNA Editing

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...

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Related Experiment Video

Updated: Mar 6, 2026

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Published on: December 3, 2019

Single-cell transcriptomics reveals specific RNA editing signatures in the human brain.

Ernesto Picardi^1,2, David S Horner³, Graziano Pesole^1,2

¹Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, 70126 Bari, Italy.

RNA (New York, N.Y.)

|March 5, 2017

Summary

RNA editing by adenosine-to-inosine (A-to-I) deamination is crucial for human brain cells. This study reveals cell-type-specific RNA editing patterns in single human brain cells, offering new insights into neuronal function.

Keywords:

RNA editing RNA-seq single cell transcriptome

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Related Experiment Videos

Last Updated: Mar 6, 2026

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Published on: December 3, 2019

Obtaining High Quality RNA from Single Cell Populations in Human Postmortem Brain Tissue

Obtaining High Quality RNA from Single Cell Populations in Human Postmortem Brain Tissue

Published on: August 6, 2009

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

Published on: October 12, 2018

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Adenosine-to-inosine (A-to-I) RNA editing is essential for human neuronal function.
Single-cell analysis of RNA editing in the human brain remains underexplored.

Purpose of the Study:

To investigate RNA editing profiles at the single-cell level in the human brain cortex.
To understand the cell-type-specific distribution of RNA editing.

Main Methods:

Analysis of RNA editing in single cells from the human brain cortex.
Utilizing data from living human subjects.

Main Results:

RNA editing levels per cell exhibit a bimodal distribution.
Distinct RNA editing patterns were identified across major brain cell types.

Conclusions:

Single-cell RNA editing analysis provides novel insights into human brain cell heterogeneity.
RNA editing patterns can differentiate between major brain cell types, impacting neuronal dynamics.