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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Treatment of pediatric-onset lupus nephritis: a proposal of optimal therapy

Hiroshi Tanaka1,2, Kensuke Joh3, Tadaatsu Imaizumi4

  • 1Department of School Health Science, Faculty of Education, Hirosaki University, Hirosaki, 036-8650, Japan. hirotana@hirosaki-u.ac.jp.

Clinical and Experimental Nephrology
|March 5, 2017
PubMed

Insights

Lupus nephritis (LN) in children requires careful management due to its link to systemic lupus erythematosus (SLE). Advances in treatment, including earlier diagnosis and targeted therapies, are improving outcomes for pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Rheumatology
  • Immunology

Background:

  • Lupus nephritis (LN) is a significant complication of childhood-onset systemic lupus erythematosus (SLE).
  • Effective and safe maintenance therapy is crucial for managing chronic SLE and preventing disease flares in pediatric patients.
  • The pathogenesis of SLE involves complex interactions between innate and adaptive immune systems.

Purpose of the Study:

  • To review current understanding and clinical practice in managing lupus nephritis (LN) in pubertal patients.
  • To highlight challenges in achieving optimal treatment outcomes for pediatric LN.
  • To discuss the role of immune system pathways in SLE pathogenesis and potential therapeutic targets.

Main Methods:

  • Review of recent advances in LN management.
  • Emphasis on early renal biopsy and selective immunosuppressive therapy.
  • Discussion of ongoing research into drugs targeting inflammatory pathways.

Main Results:

  • Advances in management, including earlier diagnosis and tailored immunosuppression, have improved outcomes for pediatric LN.
  • The balance between treatment efficacy, long-term prognosis, and adverse effects remains a critical consideration.
  • Research is exploring novel therapies targeting innate and adaptive immune responses in SLE.

Conclusions:

  • Optimal treatment strategies for pediatric lupus nephritis are evolving.
  • A careful balance of treatment benefits and risks is essential for long-term patient well-being.
  • Continued research into immunomodulatory therapies holds promise for improving SLE and LN management.

Keywords:
Immunosuppressive treatmentLupus nephritisMizoribineMultitarget therapyPediatric-onsetSystemic lupus erythematosusTacrolimus

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