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Related Concept Videos

Aquaporins01:25

Aquaporins

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Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
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The Respiratory System01:16

The Respiratory System

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The respiratory system is comprised of the organs that enable breathing. Air enters the nostrils and mouth, followed by the pharynx (throat) and larynx (voice box), which lead to the trachea (windpipe). In the thoracic cavity, the trachea splits into two bronchi that allow air to enter the lungs. The bronchi split into progressively smaller bronchioles and terminate in small groups of tiny sacs in the lungs called alveoli, where gas exchange occurs.
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Reabsorption and Secretion in the DCT and Collecting Duct01:26

Reabsorption and Secretion in the DCT and Collecting Duct

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The early phase of the DCT manages the reabsorption of approximately 10-15% of filtered water, 5–10% of filtered sodium, and 5–10% of filtered chloride. This process is facilitated by Na+–Cl− symporters in apical membranes and sodium-potassium pumps, as well as Cl− leakage channels in basolateral membranes. The early DCT also stands out as a site where parathyroid hormone (PTH) stimulates calcium reabsorption, depending on the body's requirements.
The distal...
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Alveoli and Alveolar Ducts01:26

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The respiratory zone of the human body, which stands in contrast to the conducting zone, comprises the structures that actively participate in the exchange of gases. The initiation of this zone is marked by the terminal bronchioles converging into respiratory bronchioles, the tiniest bronchiole classification. The respiratory bronchioles give way to the alveolar ducts that opens into a congregation of alveoli. Actively involved in gas exchange, alveoli resemble tiny sacs similar to clusters of...
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Overview of Respiratory System01:23

Overview of Respiratory System

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The respiratory system is a complex biological apparatus that facilitates the exchange of gases, specifically oxygen and carbon dioxide, between our bodies and the environment. This system plays a vital role in the physiological process of respiration, an essential function for sustaining life.
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The respiratory system consists of a series of organs responsible for taking in oxygen and expelling carbon dioxide. The primary function of the respiratory system is to...
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Anatomy of Respiratory System I: Upper Respiratory Tract01:29

Anatomy of Respiratory System I: Upper Respiratory Tract

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The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
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Related Experiment Video

Updated: Mar 6, 2026

Tracking Single Proteins in Lipid Bilayers Using Fluorescence Microscopy
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Aquaporins in Respiratory System.

Yuanlin Song1,2,3, Linlin Wang4, Jian Wang4

  • 1Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. song.yuanlin@zs-hospital.sh.cn.

Advances in Experimental Medicine and Biology
|March 5, 2017
PubMed
Summary

Aquaporins (AQPs) are crucial water channels in the respiratory system. Research highlights their role in lung fluid balance and disease, though further study is needed to fully understand their function.

Keywords:
AquaporinsFluid transportLung disorders

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Area of Science:

  • Physiology
  • Molecular Biology
  • Respiratory Medicine

Background:

  • Aquaporins (AQPs) are integral membrane proteins facilitating water transport.
  • AQPs are implicated in various physiological processes within the respiratory system, including alveolar fluid balance and airway humidification.

Purpose of the Study:

  • To review the expression and function of four key aquaporins (AQP1, AQP2, AQP4, AQP5) in the lungs.
  • To elucidate the role of AQPs in maintaining fluid homeostasis in the respiratory system under normal and disease conditions.

Main Methods:

  • Review of existing literature on aquaporin expression and function in lung physiology and pathology.
  • Analysis of data from model and transgenic mice to understand aquaporin roles in fluid balance.

Main Results:

  • The study focuses on AQP1, AQP2, AQP4, and AQP5 expression in lung tissues.
  • Evidence suggests significant involvement of AQPs in the pathophysiology of various lung diseases.

Conclusions:

  • Aquaporins play critical roles in respiratory system fluid balance.
  • Further research is essential to fully clarify the precise functions of AQPs in lung diseases and develop targeted therapies.