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Related Concept Videos

Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Renal Failure: Dose Adjustments01:11

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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Factors Affecting Renal Clearance: Renal Impairment01:17

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

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The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

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Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Updated: Mar 6, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Renal function assessment in heart failure.

J I Pérez Calvo1, C Josa Laorden1, I Giménez López2

  • 1Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España; Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, España; Facultad de Medicina, Universidad de Zaragoza, Zaragoza, España.

Revista Clinica Espanola
|March 5, 2017
PubMed
Summary

Renal function significantly impacts heart failure prognosis, regardless of ejection fraction. Interpreting kidney function tests requires considering the patient

Keywords:
BiomarcadoresBiomarkersCistatinaCreatininaCreatinineCystatinHeart failureInsuficiencia cardiacaInsuficiencia renalRenal failureUrea

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Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Renal function is a critical prognostic factor in heart failure.
  • Its predictive value is independent of ejection fraction and functional status.

Purpose of the Study:

  • To review renal function assessment methods in heart failure.
  • To emphasize clinical context in interpreting renal function results.
  • To discuss tubular damage biomarkers in heart failure.

Main Methods:

  • Literature review of renal function assessment in heart failure.
  • Analysis of prognostic significance of renal function.
  • Review of tubular damage biomarker performance.

Main Results:

  • Renal function consistently predicts outcomes in heart failure.
  • Clinical context and treatment response are vital for accurate interpretation.
  • Tubular damage biomarkers show potential but require further study.

Conclusions:

  • Accurate assessment of renal function is crucial for heart failure management.
  • Integrating clinical data enhances prognostic accuracy.
  • Further research on biomarkers is warranted.