Early antithrombotic treatment with warfarin oral suspension in severe neonatal protein C deficiency

Area of Science:

• Pediatrics
• Hematology
• Pharmacology

Background:

• Neonatal severe protein C deficiency presents a significant thrombotic risk.
• Current long-term preventive treatment strategies lack uniformity.
• Effective management is crucial to prevent severe complications.

Observation:

• A case of neonatal severe protein C deficiency was managed with warfarin oral suspension.
• Home monitoring of international normalized ratio (INR) was performed using a Coaguchek XS® device.
• The target INR range was maintained between 2.5 and 3.5.

Findings:

• Warfarin treatment over two years resulted in only minor purpuric episodes.
• No significant bleeding complications were reported during the treatment period.
• This approach demonstrated good safety and efficacy in the observed case.

Implications:

• Early warfarin introduction may be a viable preventive strategy for neonatal protein C deficiency.
• Home-care monitoring empowers families and potentially reduces healthcare burden.
• Parental education programs are vital for successful long-term management of this rare condition.