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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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Consensus classification of posterior cortical atrophy.

Sebastian J Crutch¹, Jonathan M Schott¹, Gil D Rabinovici²

¹Dementia Research Centre, UCL Institute of Neurology, London, UK.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|March 6, 2017

Summary

This summary is machine-generated.

A new classification framework for posterior cortical atrophy (PCA) standardizes syndrome definition across research settings. This consensus-based approach refines PCA criteria for improved data interpretation and collaborative studies.

Keywords:

Alzheimer's disease Biomarker Clinico-radiological syndrome Pathophysiology Posterior cortical atrophy

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Area of Science:

Neurology
Neuroscience
Clinical Diagnostics

Background:

Posterior Cortical Atrophy (PCA) lacks uniform diagnostic criteria, hindering research consistency.
A consensus framework is proposed to standardize PCA definition in diverse research environments.

Framework:

A three-level classification system for PCA is presented, encompassing syndrome and disease levels.
Level 1 defines core PCA features and exclusions; Level 2 differentiates PCA-pure and PCA-plus.
Level 3 identifies underlying causes (e.g., PCA-AD, PCA-LBD) using biomarker evidence.

Implementation:

Developed through literature review and international multidisciplinary expert consensus.
Informed by a quantitative survey on PCA symptom frequency and conceptualization.

Implications:

Enhances uniformity in defining posterior cortical atrophy (PCA) for research.
Facilitates cross-study data interpretation and application in clinical trials.
Provides a foundation for future collaborative research on PCA and related neurodegenerative conditions.