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Updated: Mar 6, 2026

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Resistance to metronomic chemotherapy and ways to overcome it

Maria Riesco-Martinez1, Karla Parra2, Ronak Saluja3

  • 1Division of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.

Cancer Letters
|March 6, 2017
PubMed

Insights

Therapeutic resistance in cancer is a major challenge. This review summarizes resistance mechanisms specific to metronomic chemotherapy, highlighting preclinical targets for overcoming this resistance.

Area of Science:

  • Oncology
  • Cancer Therapy
  • Drug Resistance

Background:

  • Therapeutic resistance significantly contributes to cancer mortality.
  • Antivascular therapies, including vascular endothelial growth factor pathway inhibitors, face inherent or acquired resistance.
  • Mechanisms of resistance to these therapies differ from conventional cytotoxic treatments.

Purpose of the Study:

  • To summarize the specific mechanisms of resistance observed in metronomic chemotherapy.
  • To identify promising preclinical molecular targets and pathways for overcoming metronomic chemotherapy resistance.

Main Methods:

  • Literature review of studies on resistance to metronomic chemotherapy.
  • Analysis of preclinical findings on molecular targets and pathways.

Main Results:

  • Novel resistance mechanisms identified for vascular endothelial growth factor pathway inhibitors may also apply to metronomic chemotherapy.
  • Several preclinical molecular targets and pathways show potential for enhancing metronomic chemotherapy efficacy.

Conclusions:

  • Understanding resistance mechanisms is crucial for improving cancer treatment outcomes.
  • Preclinical strategies exist to overcome metronomic chemotherapy resistance, but clinical translation faces challenges.
Keywords:
Antivascular tumor therapyChemoresistanceMetronomic chemotherapyTherapeutic resistance

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