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The Pancreatic Islet Regulome Browser.

Loris Mularoni1, Mireia Ramos-Rodríguez2, Lorenzo Pasquali3

  • 1Research Program on Biomedical Informatics, IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu FabraBarcelona, Spain; Biomedical Genomics, Institute for Research in Biomedicine, The Barcelona Institute of Science and TechnologyBarcelona, Spain.

Frontiers in Genetics
|March 7, 2017
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Summary

The Islet Regulome Browser provides integrated genomic data for pancreatic islet cells. This tool aids research into glucose metabolism disorders and diabetes by exploring regulatory elements and transcription factor binding sites.

Keywords:
epigenomegene regulationnon-coding DNApancreatic isletβ-cells

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Area of Science:

  • Endocrinology
  • Genomics
  • Computational Biology

Background:

  • Pancreatic islets regulate glucose homeostasis, and understanding their transcriptional control is key to metabolic disorders.
  • The non-coding genome's tissue-specific functions are deciphered through transcriptomic and epigenomic data analysis.
  • Previous research lacked a centralized platform for exploring pancreatic islet genomic data.

Purpose of the Study:

  • To present the Islet Regulome Browser, a tool for accessing and exploring pancreatic islet epigenomic and transcriptomic data.
  • To facilitate the identification of regulatory variants involved in glucose metabolism and diabetes.
  • To provide a comprehensive resource for functional genomics studies in pancreatic islet research.

Main Methods:

  • Integrative computational analysis of transcriptomic and epigenomic data.
  • Development of a web-based and locally installable browser for genomic data exploration.
  • Integration of data including Genome-Wide Association Studies (GWAS) variants, regulatory elements, and transcription factor binding sites.

Main Results:

  • The Islet Regulome Browser offers fast access to diverse pancreatic islet genomic datasets from multiple labs.
  • It enables interactive exploration of regulatory elements, enhancer clusters, and transcription factor binding sites in human pancreatic progenitors and islets.
  • Users can upload custom tracks for personalized data analysis.

Conclusions:

  • The Islet Regulome Browser enhances access to public genomic datasets for pancreatic islet research.
  • It supports a deeper understanding of regulatory networks controlling tissue-specific transcription.
  • The tool is expected to significantly advance functional genomics studies related to glucose metabolism and diabetes.