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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
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Assessment of Diastolic Function in Congenital Heart Disease

Dilveer Kaur Panesar1, Michael Burch2

  • 1Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; Centre for Cardiovascular Imaging, Institute of Cardiovascular Science, University College London, London, UK.

Frontiers in Cardiovascular Medicine
|March 7, 2017
PubMed

Insights

Diastolic dysfunction can cause heart failure symptoms despite normal systolic function. This review details assessing diastolic function in congenital heart disease, considering lesion effects and advanced techniques.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Diastolic function is a critical aspect of left ventricular (LV) function.
  • Diastolic dysfunction can manifest as heart failure symptoms, even with preserved systolic function.
  • Assessing diastolic function is complex, particularly in congenital heart disease (CHD) due to lesion-specific effects.

Purpose of the Study:

  • To review the assessment of diastolic function in congenital heart disease.
  • To discuss the impact of specific congenital heart lesions on diastolic parameters.
  • To highlight recent advancements in load-independent assessment techniques.

Main Methods:

  • Review of current literature on diastolic function assessment in CHD.
  • Discussion of flow-dependent and load-independent measurement techniques.
  • Integration of inflow velocities and tissue Doppler measurements for LV filling pressure estimation.

Main Results:

  • Diastolic function parameters are often flow-dependent and influenced by loading conditions.
  • Congenital heart lesions significantly alter diastolic function parameters.
  • Load-independent techniques offer more accurate assessments of ventricular compliance and remodeling.

Conclusions:

  • Accurate assessment of diastolic function in CHD requires understanding lesion-specific impacts.
  • Combined inflow and tissue Doppler methods aid in estimating diastolic function and LV filling pressures.
  • Advanced techniques improve the evaluation of diastolic function in complex congenital heart disease.

Keywords:
CMRcongenital heart diseasediastolic functiondiastolic heart failureechocardiography

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