Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive
Asja Pettignano1, Santiago Grijalvo2, Marleen Häring3
1Institute of Organic Chemistry, University of Regensburg, Universitaetsstr. 31, 93040 Regensburg, Germany. david.diaz@ur.de and Institut Charles Gerhardt, UMR 5253 CNRS/UM/ENSCM, Matériaux Avancés pour la Catalyse et la Santé, ENSCM, 8 rue Ecole Normale, 34296 Montpellier Cedex 5, France.
Abstract:
One-step functionalization of alginate with boronic acid groups allowed spontaneous formation of biocompatible hydrogels under basic conditions without additional complementary molecules or crosslinking agents. The dynamic nature of boronate ester bonds formed with vicinal diols present on alginate pyranose rings provided remarkable self-healing, injectable and multi-stimuli responsive properties to the material.
