Callosal size in first-episode schizophrenia patients with illness duration of less than one year: A cross-sectional MRI study

Previous studies have reported a reduction in the size of the corpus callosum (CC) on the mid-sagittal plane in patients with schizophrenia. However, findings for the size of the callosal area in patients with first-episode schizophrenia (FESz) are inconsistent. A possibility for these conflicting results is that the duration of illness in patients with FESz affects the CC size. The present study investigated the CC size abnormalities in patients with FESz. Forty-six patients with FESz whose duration of illness was less than 1year and 46 age-, sex-, and handedness-matched healthy controls were recruited to examine the CC size using magnetic resonance imaging. We measured the area of the CC using the Witelson's scheme, which divided the whole area into seven subdivisions. Analysis of covariance indicated there was no difference in the whole or regional areas of the CC between patients with FESz and healthy controls. The rostrum of the CC was significantly correlated with the total score for negative symptoms and some of the subtotal scores. Our findings indicate that there was no reduction in the whole or regional area of the CC among patients with FESz. When comparing the callosal morphology and symptoms, negative symptoms increased in severity as the rostrum area of the CC decreased in size. Further studies are needed to investigate whether the size of the anterior CC is associated with the pathology observed in the early stages of FESz.