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Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Quantitative structure-chromatographic retention correlations of quinoline derivatives
Nadezhda A Nekrasova1, Svetlana V Kurbatova2
1Department of Physical Chemistry and Chromatography, Samara National Research University Named after Academician S.P. Korolev, 34 Moskovskoye Shosse, 443086, Samara, Russia; Samara Center for Theoretical Materials Science, 34 Moskovskoye Shosse, 443086, Samara, Russia.
Abstract:
The aim of our study was to investigate relationships between quinoline derivatives structure and their retention under reversed-phase liquid chromatography conditions. Retention factors of quinolines were experimentally measured and various geometrical and physicochemical parameters representing analytes molecular structure were calculated. Equations connecting chromatographic data with computed characteristics for the set of 17 investigated compounds were constructed. It was shown that the most precise dependencies include combination of physico-chemical and geometrical parameters.
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