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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Highly potent stem cells from full-term amniotic fluid: A realistic perspective.

Adila A Hamid1, Muhammad Khair Joharry2, Hoo Mun-Fun2

  • 1Stem Cell Research Laboratory, Department of Biomedical Science, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia; Genetics & Regenerative Medicine Research Centre, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia; Department of Physiology, Faculty of Medicine, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Reproductive Biology
|March 7, 2017
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Summary

Full-term amniotic fluid may contain potent stem cells, offering a safer alternative to mid-term amniotic fluid stem cells. This review explores the potential of these valuable stem cells for cell therapy.

Keywords:
Amniotic fluid mesenchymal stem cellsAmniotic fluid stem cellsFull-term amniotic fluidPluripotent

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Perinatology

Background:

  • Amniotic fluid (AF) contains potent stem cells valuable for cell therapy.
  • Current isolation methods primarily use mid-term pregnancy AF via invasive amniocentesis, posing risks.
  • Full-term AF, often discarded, presents a potential alternative source.

Purpose of the Study:

  • To review the potential of full-term amniotic fluid as a source of highly potent stem cells.
  • To investigate the origin and content of AF across gestation.
  • To compare stem cell potency from mid-term versus full-term AF.

Main Methods:

  • Literature review focusing on AF origin, content, and stem cell isolation.
  • Comparative analysis of stem cell studies from mid-term and full-term AF in various species.
  • Discussion on the distinctness and potential potency of full-term AF stem cells.

Main Results:

  • Mid-term AF stem cell isolation is invasive and carries risks.
  • Full-term AF is an underutilized resource.
  • Evidence suggests full-term AF may harbor distinct and potentially more potent stem cells than AF-MSCs.

Conclusions:

  • Full-term amniotic fluid is a promising, non-invasive source for potent stem cells.
  • Further research is warranted to explore the therapeutic potential of full-term AF stem cells.
  • These cells could offer a safer and more accessible option for cell-based therapies.