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A second catalytic subunit of type-2A protein phosphatase from rabbit skeletal muscle
O B da Cruz e Silva1, P T Cohen
1Department of Biochemistry, University of Dundee, Scotland.
FEBS Letters
|December 21, 1987
Abstract:
A cDNA clone encoding a second type-2A protein phosphatase catalytic subunit (2A beta) was isolated from a rabbit skeletal muscle cDNA library constructed in lambda gt10. The deduced protein sequence (309 residues, 35.59 kDa) was 97% identical to that of phosphatase 2A alpha (309 residues, 35.58 kDa). At the nucleotide level, the two clones showed only 82% identity in the coding region. The results indicate the presence of at least two isoforms of protein phosphatase 2A in skeletal muscle.